Summary
Foetal trimethadione syndrome is a foetopathy likely to occur when a pregnant woman takes trimethadione for epileptic seizures. Trimethadion used to be one of the main anticonvulsants, but the drug has been withdrawn from the market because of the associated side effects and the availability of better medications. The signs of "trimethadione syndrome" described in offspring of women treated with this drug are similar to those connected to other anticonvulsants and include pre- and post-natal growth retardation, intellectual deficit, developmental and speech delay, craniofacial anomalies (such as malformed low-set ears, cleft lip and/or palate, microcephaly, epicanthus, teeth anomalies and broad nasal bridge), and malformations of the heart, urogenital system and distal limb structures. *Author: Dr E. Robert-Gnansia (February 2006)*.
