Summary
Vitamin D resistant rickets is defined by its resistance to the vitamin D treatment generally used in deficiency rickets. Typical signs are observed from the first months of life: radiological signs of defective mineralization on cartilage growth plates (rickets) and bones (osteomalacia) and alterations of the phosphocalcic homeostasis in spite of a satisfactory vitamin D status. The clinical phenotype combines bone deformities, mainly at the lower limbs, and other signs depending upon the etiology of the resistance (see below). Two groups of hereditary resistant rickets should be distinguished: hypophosphatemic rickets and pseudo-deficiency rickets.* Author: Dr M. Garabedian (January 2002)*.
