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Orpha number ORPHA2495
Synonym(s) -
Prevalence 1-9 / 100 000
Inheritance -
Age of onset -
  • D32.9
  • C0025286
  • D008579
  • 10027191
  • 19453003


Meningioma is mostly a benign primary tumor of the meninges (arachnoid cap cells), which show raising incidence with age and are most common in the sixth and seventh decade of life. The majority of meningiomas are located in the supratentorial compartment and the less common sites include the optic nerve sheath, cerebellopontine angle, and choroid plexus. Less than 10% of meningiomas are clinically apparent, causing hyperostosis close to the tumor and resulting in focal bulging and localized pain. Additional features may include headache, seizures, gradual personality changes (apathy and dementia), anosmia, impaired vision, exophthalmos, hearing loss, ataxia, dysmetria, hypotonia and nystagmus. Rarely, spontaneous bleeding occurs. Most neurofibromatosis type 2 (see this term) patients develop meningioma that characteristically present earlier in life. The large majority, approximately 80%, of meningiomas can be cured by surgery.

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Detailed information

Review article
  • IT (2008)
  • EN (2008)
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