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Cobb syndrome

Disease definition

Cobb syndrome is defined by the association of vascular cutaneous (venous or arteriovenous), muscular (arteriovenous), osseous (arteriovenous) and medullary (arteriovenous) lesions at the same metamere or spinal segment. This segmental distribution may involve one or many of the 31 metameres present in humans. Only 16% of the medullary lesions are multiple and have a clearly metameric distribution.

ORPHA:53721

  • Synonym(s):
    • Cutaneomeningospinal angiomatosis
    • SAMS 1-31
    • Spinal arteriovenous metameric syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: Q27.3
  • OMIM: -
  • UMLS: C0346068
  • MeSH: -
  • GARD: 11892
  • MedDRA: 10068841

Additional information

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