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Dense deposit disease

Disease definition

Dense deposit disease, a histological subtype of MPGN (see this term) is an idiopathic chronic progressive kidney disorder distinguished by the presence of intra-membranous dense deposits in addition to immune complex subendothelial deposits in the glomerular capillary walls. This form often has a higher recurrence rate after a kidney transplant and is associated with extra-renal manifestations such as familial drusen (see this term).

ORPHA:93571

  • Synonym(s):
    • Membranoproliferative glomerulonephritis type 2
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Childhood
  • ICD-10: N04.6
  • OMIM: 609814
  • UMLS: C0268743
  • MeSH: D015432
  • GARD: 8555
  • MedDRA: -

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