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Familial partial lipodystrophy, Dunnigan type

Disease definition

Familial Partial lipodystrophy, Dunnigan type (FPLD2) is a rare form of genetic lipodystrophy (see this term) characterized by a loss of subcutaneous adipose tissue from the trunk, buttocks and limbs; fat accumulation in the neck, face, axillary and pelvic regions; muscular hypertrophy; and usually associated with metabolic complications such as insulin resistance, diabetes mellitus, dyslipidemia and liver steatosis.

ORPHA:2348

  • Synonym(s):
    • Dunnigan syndrome
    • FPLD2
    • Familial partial lipodystrophy type 2
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant 
  • Age of onset: Adolescent, Adult
  • ICD-10: E88.1
  • OMIM: 151660
  • UMLS: C1720860
  • MeSH: -
  • GARD: 3126
  • MedDRA: -

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