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American trypanosomiasis

Disease definition

American trypanosomiasis, commonly known as Chagas disease (ChD), is a tropical disease mainly found in latin America and transmitted by triatomine insects (mostly Triatoma infestans and Rhodnius prolixus and Panstrongylus megistus) harboring the hemoflagellate protozoan parasite Trypanosoma cruzi. The disease is characterized by an acute phase which is either asymptomatic or manifest with fever, inflammation at the inoculation site (inoculation chancre or chagoma), unilateral palpebral edema called the Romaña sign (when the triatomine bite occurs near the eye), enlarged lymph nodes, and splenomegaly. The chronic phase is lifelong and development of chagasic cardiomyopathy (30%; complex arrhythmias, heart failure, and thromboembolic events), digestive (10%; megaoesophagus and megacolon), neurological (10%; stroke, peripheral neuropathy and autonomic dysfunction), or mixed alterations (10%) may be observed. These can all lead to high morbidity and mortality rates.

ORPHA:3386

  • Synonym(s):
    • Chagas disease
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: B57.0  B57.1  B57.2  B57.3  B57.4  B57.5
  • OMIM: -
  • UMLS: C0041234
  • MeSH: -
  • GARD: -
  • MedDRA: 10001935

Additional information

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