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Cutaneous leukocytoclastic angiitis

ORPHA889
Synonym(s) Cutaneous hypersensitivity vasculitis
Cutaneous small vessel vasculitis
Prevalence Unknown
Inheritance Not applicable
Age of onset All ages
ICD-10
  • M31.0
OMIM -
UMLS -
MeSH -
MedDRA -

Summary

Cutaneous leukocytoclastic vasculitis is a small-vessel vasculitis presenting with palpable purpura and urticarial lesions which predate the purpuric lesions most frequently observed on the legs. Systemic symtoms including fever, cough, hemoptysis, sinusitis, arthralgia, arthritis, myalgia, abdominal pain, diarrhea, hematochezia, paresthesia, weakness, and hematuria may be observed. Skin biopsy reveals exudates rich in neutrophils, endothelial damage, fibrin deposition, and leukocytoclasis in postcapillary venules of small vessels. Cutaneous leukocytoclastic vasculitis can be idiopathic (up to 50% of cases) or secondary to infection, medications (such as antituberculosis medication), collagen vascular diseases, or neoplasms.


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Detailed information

Review article
  • EN (2005,pdf)
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