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Leber hereditary optic neuropathy

Disease definition

Leber's hereditary optic neuropathy (LHON) is a mitochondrial neurodegenerative disease affecting the optic nerve and often characterized by sudden vision loss in young adult carriers.

ORPHA:104

  • Synonym(s):
    • LHON
    • Leber optic atrophy
  • Prevalence: 1-9 / 100 000
  • Inheritance: Mitochondrial inheritance 
  • Age of onset: Adolescent, Adult
  • ICD-10: H47.2
  • OMIM: 308905  535000
  • UMLS: -
  • MeSH: -
  • GARD: 6870
  • MedDRA: -

Detailed information

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