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Feingold syndrome

Synonym(s) Brunner-Winter syndrome
Digital anomalies with short palpebral fissures and atresia of esophagus or duodenum
MODED syndrome
Microcephaly-digital anomalies-normal intelligence syndrome
Microcephaly-intellectual disability-tracheoesophageal fistula syndrome
Microcephaly-oculo-digito-esophageal-duodenal syndrome syndrome
ODED syndrome
Oculo-digito-esophageal-duodenal syndrome
Prevalence <1 / 1 000 000
Inheritance Autosomal dominant
Age of onset Neonatal
  • Q87.8
MeSH -
MedDRA -


Disease definition

Feingold syndrome (FS), also known as oculo-digito-esophageal-duodenal (ODED) syndrome, is a rare inherited malformation syndrome characterized by microcephaly, short stature and numerous digital anomalies and is comprised of two subtypes: FS type 1 (FS1) and FS type 2 (FS2) (see these terms). FS1 is by far the most common form while FS2 has only been reported in 3 patients and has the same clinical characteristics as FS1, apart from the absence of gastrointestinal atresia and short palpebral fissures.

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  • Pr Loïc DE PONTUAL

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