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Feingold syndrome

Disease definition

Feingold syndrome (FS), also known as oculo-digito-esophageal-duodenal (ODED) syndrome, is a rare inherited malformation syndrome characterized by microcephaly, short stature and numerous digital anomalies and is comprised of two subtypes: FS type 1 (FS1) and FS type 2 (FS2) (see these terms). FS1 is by far the most common form while FS2 has only been reported in 3 patients and has the same clinical characteristics as FS1, apart from the absence of gastrointestinal atresia and short palpebral fissures.

ORPHA:1305

  • Synonym(s):
    • Brunner-Winter syndrome
    • Digital anomalies with short palpebral fissures and atresia of esophagus or duodenum
    • FGLDS
    • FS
    • MMT
    • MODED syndrome
    • Microcephaly-digital anomalies-normal intelligence syndrome
    • Microcephaly-intellectual disability-tracheoesophageal fistula syndrome
    • Microcephaly-oculo-digito-esophageal-duodenal syndrome syndrome
    • ODED syndrome
    • Oculo-digito-esophageal-duodenal syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Neonatal
  • ICD-10: Q87.8
  • OMIM: 164280  614326
  • UMLS: C0796068
  • MeSH: -
  • GARD: 8407
  • MedDRA: -

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