Articular chondrocalcinosis is a chronic articular disease characterized by acute intermittent attacks of arthritis, the presence of calcium pyrophosphate crystals in synovial fluid, cartilage and periarticular soft tissue and calcium deposition in articular cartilage. Chondrocalcinosis occurs in 3 forms: a hereditary form; a form associated with metabolic disorders such as hyperparathyroidism, hemochromatosis, hypothyroidism and Wilson disease; and a sporadic form, which may in some cases represent the hereditary form. The familial form represents a fourth of all cases. It is inherited as a dominant autosomal trait with variable penetrance.
Last update: March 2002