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Cerebral cavernous malformations

Synonym(s) Brain cavernous angioma
Brain cavernous hemangioma
Cerebral cavernoma
Prevalence >1 / 1000
Inheritance Not applicable
Age of onset All ages
  • D18.0
  • C2919945
MeSH -
  • 10071747


Cerebral cavernous malformations (CCMs) are vascular malformations composed of closely clustered irregular dilated capillaries. CCMs are mostly located in the brain and spinal cord and sometimes in retina and skin. CCMs can occur either as a sporadic condition or as an autosomal dominant disorder (familial CCM; see this term). Sporadic cases harbor only one lesion and are most often asymptomatic and are not rare. When symptomatic, a patient with a CCM may present with seizures, non-specific headaches, progressive or transient focal neurologic deficits, and/or cerebral hemorrhages.

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