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Gollop-Wolfgang complex is a very rare malformation characterized by ectrodactyly of the hand and ipsilateral bifurcation of the femur.
Approximately 200 cases have been reported worldwide.
Congenital aplasia/hypoplasia of the tibia, accompanied by pre-axial oligodactyly or monodactyly of the feet, may also be present. In most cases, the bifurcation of the distal femur is unilateral. Around 80% of patients present with major aplasia without metacarpophalangeal bones, which is sometimes associated with an abnormality of the ulna. Patients are often small.
The etiology remains unknown.
Diagnosis is based on clinical and radiological evidence.
Hypoplastic tibia-polydactyly syndrome (see this term) is the main differential diagnosis.
Prenatal diagnosis is possible by ultrasound.
Autosomal dominant and autosomal recessive modes of transmission have been suggested.
Management and treatment
Patients should be offered orthopedic and reconstructive surgery (involving prosthetics) and regular monitoring.
Life expectancy is not reduced but, in the absence of treatment, the functional prognosis is poor.