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MASA syndrome

Synonym(s) Intellectual disability-aphasia-shuffling gait-adducted thumbs syndrome
Prevalence Unknown
Inheritance X-linked recessive
Age of onset Neonatal
  • G11.4
  • C0795953
  • C536029
MedDRA -


Disease definition

MASA syndrome (Mental retardation, Aphasia, Spastic paraplegia, Adducted thumbs) is a historical term used to describe a phenotype now considered to be part of the X-linked L1 clinical spectrum (L1 syndrome, see this term). MASA is characterized by mild to moderate intellectual deficit, delayed development of speech, hypotonia progressing to spasticity or spastic paraplegia, adducted thumbs, and mild to moderate distension of the cerebral ventricles.

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Detailed information

Summary information
Review article
Article for general public
Clinical genetics review
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