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Osteodysplasty, Melnick-Needles type

Synonym(s) Melnick-Needles syndrome
Prevalence <1 / 1 000 000
Inheritance X-linked dominant
Age of onset Childhood
  • Q77.8
  • C0025237
MeSH -
  • 10060908


Osteodysplasty, Melnick-Needles type (MNS) is a severe form of frontootopalatodigital syndrome (see this term) and is associated with a short stature, facial dysmorphism, osseous abnormalities involving the majority of the axial and appendicular skeleton resulting in significant effects on the craniofacial skeleton including impaired speech and masticatory problems.

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Detailed information

Clinical genetics review
  • EN (2013)
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