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Fetal cytomegalovirus syndrome

ORPHA294
Synonym(s) Antenatal CMV infection
Antenatal cytomegalovirus infection
Prevalence 1-5 / 10 000
Inheritance Not applicable
Age of onset Neonatal
Antenatal
ICD-10
  • P35.1
OMIM -
UMLS
  • C0349499
MeSH -
MedDRA -

Summary

Fetal cytomegalovirus (CMV) syndrome is a fetopathy that is likely to occur when a CMV-infected pregnant woman transmit the virus in utero. Children born with congenital CMV infection may present hepatomegaly, splenomegaly, jaundice, pneumonitis, fetal growth retardation, petichiae (blueberry muffin-like rash), purpura and thrombocytopenia. Moreover, congenital CMV infection can result in major neurological sequelae, including microcephaly, intracranial calcifications, sensorineural hearing loss, chorioretinitis, intellectual and motor disabilities and seizure disorders. CMV disease sequelae caused by primary infection are usually more severe than disease caused by reactivation of a latent infection.


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