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Fatal familial insomnia

Disease definition

Fatal familial insomnia (FFI) is a very rare form of prion disease (see this term) characterized by subacute onset of insomnia showing as a reduced overall sleep time, autonomic dysfunction, and motor disturbances.

ORPHA:466

  • Synonym(s): -
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Adult
  • ICD-10: A81.8
  • OMIM: 600072
  • UMLS: C0206042
  • MeSH: D034062
  • GARD: 6429
  • MedDRA: 10072077

Detailed information

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