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Fatal familial insomnia

Synonym(s) -
Prevalence <1 / 1 000 000
Inheritance Autosomal dominant
or Not applicable
Age of onset Adult
  • A81.8
  • C0206042
  • D034062
  • 10072077


Fatal familial insomnia (FFI) is a very rare form of prion disease (see this term) characterized by subacute onset of insomnia showing as a reduced overall sleep time, autonomic dysfunction, and motor disturbances.

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Clinical genetics review
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