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Acute promyelocytic leukemia

Orpha number ORPHA520
Synonym(s) Acute myeloblastic leukemia type 3
Acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants
Prevalence Unknown
Inheritance -
Age of onset Variable
  • C92.4
  • C0023487
  • D015473
  • 10001019
  • 28950004


Acute promyelocytic leukemia (APL) is an aggressive form of acute myeloid leukemia (AML; see this term), characterized by arrest of leukocyte differentiation at the promyelocyte stage, in most cases due to a specific chromosomal translocation t(15;17) in the blood and bone marrow. APL manifests with easy bruising, hemorragic diathesis and fatigue.

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Detailed information

Summary information
Review article
  • EN (2008)
Clinical practice guidelines
  • FR (2011)
Article for general public
  • IT (2008)
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