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Thrombotic thrombocytopenic purpura

Disease definition

Thrombotic thrombocytopenic purpura (TTP) is an aggressive and life-threatening form of thrombotic microangiopathy (TMA; see this term) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and organ failure of variable severity and is comprised of congenital TTP and acquired TTP (see these terms).

ORPHA:54057

  • Synonym(s):
    • Moschcowitz disease
    • TTP
  • Prevalence: 1-5 / 10 000
  • Inheritance: Autosomal recessive or Multigenic/multifactorial 
  • Age of onset: All ages
  • ICD-10: M31.1
  • OMIM: 274150
  • UMLS: C0034155
  • MeSH: D011697
  • GARD: -
  • MedDRA: 10043648

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