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Primary membranoproliferative glomerulonephritis

Synonym(s) MPGN
Mesangiocapillary glomerulonephritis
Prevalence 1-5 / 10 000
Inheritance -
Age of onset -
  • N00.5
  • C0017662
  • D015432
  • 10018370


Disease definition

Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive kidney disorder characterized by glomerular capillary wall structural changes and mesangial cell proliferation leading to nephrotic syndrome, hypocomplementemia, hypertension, proteinuria and end-stage kidney disease. MPGN can be due to either idiopathic (type 1, 2 and 3 MPGN; see these terms) or secondary (associated with infectious and immune complex diseases) causes.

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