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Squamous cell carcinoma of head and neck

Disease definition

Squamous cell carcinoma of head and neck (SCCHN) is a highly malignant neoplasm that can occur on the lip, oral cavity, nasal cavity, pharynx, larynx and paranasal sinuses and that accounts for 90% of all head and neck cancers, occurring most frequently in adults between the ages of 40-60. SCCHN presents with a variety of manifestations, depending on the primary site, such as voice hoarsness, dysphagia, ulceration of oral mucosa, hearing loss, epistaxis, nasal obstruction and enlargement of a cervical lymph node (neck secondaries) and is often associated with extensive invasion into surrounding tissues and a rapid metastasis to distant organs.

ORPHA:67037

  • Synonym(s):
    • HNSCC
    • Head and neck squamous cell carcinoma
  • Prevalence: 1-5 / 10 000
  • Inheritance: Multigenic/multifactorial or Not applicable 
  • Age of onset: All ages
  • ICD-10: -
  • OMIM: 275355
  • UMLS: C1168401
  • MeSH: C535575
  • GARD: 8503
  • MedDRA: 10060121

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