Skip to
  1. Homepage
  2. Rare diseases
  3. Search
Simple search

Simple search

(*) mandatory field


Other search option(s)


Synonym(s) -
Prevalence Unknown
Inheritance Autosomal dominant
or Not applicable
Age of onset Infancy
  • C69.2
  • C0035335
  • D012175
  • 10038916


Disease definition

Retinoblastoma (RB) is the most common intraocular malignancy in children. It is a life threatening neoplasia but is potentially curable. RB can be hereditary or non hereditary, unilateral or bilateral.


RB has an incidence of approximately 1/15-20,000 in Europe.

Clinical description

RB manifests most often in young children (90% of cases <3 years old). Early clinical signs are leukocoria and strabismus. RB is most often painless and children rarely complain of visual impairment despite its rapid progression towards loss of vision in the affected eye. Macular involvement is dictated by tumor location and size at diagnosis. Other rare signs include hypopyon, vitreous hemorrhage, non rhegmatogenous retinal detachment, neovascular glaucoma and orbital cellulitis. In later stages, rarely seen in high income countries (HIC), intracranial dissemination and hematagenous metastasis, mainly to bones are observed and are life-threatening. Most retinoblastomas (60%) are unilateral. Hereditary RB refers to those that arise due to a genetic predisposition (irrespective of family history); patients usually have a bilateral disease and are at increased risk to develop secondary tumors mainly sarcoma but also, pineoblastoma (see this term)/supra-sellar tumor (both named ''trilateral retinoblastoma''), glial tumor (see this term), melanoma and carcinoma.


RB is caused by inactivating mutations of both alleles of RB1 (13q14) with a high (90%) penetrance (RB risk) in most mutations. Some mutations have a low penetrance (asymptomatic carriers or unilateral RB). Monosomy 13q14 (see this term) also causes RB.

Diagnostic methods

Diagnosis is mainly clinical: Indirect ophthalmoscopy supported by fundal photography. Orbital ultrasound delineates intraocular tumor and usually shows calcification. MRI imaging is used to evaluate intra / extraocular and intracranial extension. Tumor staging (i.e. bone marrow examination, lumbar puncture and/or radionuclide bone scan) should be performed only in patients at risk of extra-ocular metastases.

Differential diagnosis

Differential diagnoses, particularly in unilateral cases, include anterior chamber or lens abnormalities especially PHPV (persistence of hyperplastic vitreous), toxocariasis, X-linked retinoschisis, uveitis, medulloepithelioma, von Hippel disease, Norrie disease, retinopathy of prematurity and Coats disease (the most difficult differential diagnosis) (see these terms).

Antenatal diagnosis

Prenatal and preimplantation genetic diagnoses are available in specialized centers in most HIC.

Genetic counseling

Patients with hereditary RB inherit RB1 mutation from a parent and thus the predisposition to RB is transmitted in an autosomal dominant manner. However, 75% of predisposed patients do not inherit the mutated RB1 from an affected parent, but might have had a de novo mutation in a parental gamete or post-zygotically. Genetic testing needs to be performed in all patients and their families.

Management and treatment

Treatment requires a multidisciplinary highly specialized approach. In HIC, conservative treatments for at least one eye are possible in most bilateral cases and increasingly used in unilateral cases. Laser treatment alone or combined with systemic chemotherapy, cryotherapy and brachytherapy are very efficient tools; local chemotherapy delivery is currently being developed. Enucleation is still frequently used in large unilateral RB as well as in bilateral with large unilateral tumor. External beam radiotherapy is only rarely used (risk of late effects, including second cancers).


Vital prognosis is excellent in HIC. Eye preservation is possible with early diagnosis. After conservative treatment, visual prognosis depends on macular involvement. If not treated promptly, RB may rapidly metastasize and be fatal, which is still frequent in low income countries.

Expert reviewer(s)

  • Dr Hervé BRISSE
  • Dr Laurence DESJARDINS
  • Pr François DOZ
  • Dr Claude HOUDAYER
  • Pr Dominique STOPPA-LYONNET

(*) Required fields.

Attention: Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Detailed information

Summary information
Review article
Clinical practice guidelines
Guidance for genetic testing
Article for general public
Clinical genetics review
Disability factsheet
Get Acrobat Reader
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.