Lissencephaly syndrome, Norman-Roberts type is characterised by the association of lissencephaly type I with craniofacial anomalies (severe microcephaly, a low sloping forehead, a broad and prominent nasal bridge and widely set eyes) and postnatal growth retardation.Last update: March 2008
The prevalence is unknown.
Severe intellectual deficit, spasticity and epilepsy are also present.
Mutations in the RELN gene (7q22) have been identified in some patients.
Transmission is autosomal recessive.