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Lethal ataxia with deafness and optic atrophy

Orpha number ORPHA1187
Synonym(s) Arts syndrome
Prevalence <1 / 1 000 000
Inheritance X-linked recessive
Age of onset Infancy
Neonatal
ICD-10
  • E79.8
ICD-O -
OMIM
UMLS
  • C0796028
MeSH
  • C535388
MedDRA -

Summary

This syndrome (also known as Arts syndrome) is characterized by intellectual deficit, early-onset hypotonia, ataxia, delayed motor development, hearing impairment and loss of vision due to optic atrophy. It was initially described in 12 male members from five generations of a Dutch family. Arts syndrome has also been described in one Australian family. Other manifestations included floppiness, susceptibility to infections, and later, flaccid tetraplegia and areflexia. Arts syndrome is transmitted as an X-linked recessive trait. It is caused by missense mutations in the phosphoribosyl pyrophosphate synthetase 1 gene (PRPS1) localized to Xq22.1-q24, leading to impaired purine biosynthesis. The disease has a fatal course during childhood (the majority of patients die before the age of 5 years) due to the high susceptibility of the patients to infections, especially of the upper respiratory tract. Treatment with S-adenosylmethionine may be beneficial and is currently under evaluation.


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Detailed information

Clinical genetics review
  • EN (2011)
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