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Schistosomiasis

Orpha number ORPHA1247
Synonym(s) -
Prevalence <1 / 1 000 000
Inheritance Not applicable
Age of onset All ages
ICD-10
  • B65.0
  • B65.1
  • B65.2
  • B65.3
  • B65.8
  • B65.9
ICD-O -
OMIM
UMLS
  • C0036323
MeSH
  • D012552
MedDRA
  • 10039603

Summary

Schistosomiasis is a parasitic disease caused by flat worms of the Schistosoma genus that, in their adult form, infect the portal venous system. Infection with larvae that penetrate the skin occurs whilst patients are bathing in contaminated stagnant freshwater in tropical zones. The invasive phase is characterized by fever, allergic reactions, and hypereosinophilia. During the stationary phase of urinary forms caused by Schistosoma haematobium, the main sign is hematuria. Long-term invasion of the urinary tract may result in terminal renal failure. This species is found in Africa, Madagascar, and in the Middle East. Intestinal and rectal forms cause portal hypertension and are due to S. mansoni (Africa, Madagascar, Latin America, West Indies), S. intercalatum (Central Africa), S. japonicum (Asia) and S. mekongi (Indochinese peninsula). Praziquantel is the drug of choice against all species.

Expert reviewer(s)

  • Dr Luc PARIS

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