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Hereditary nonpolyposis colon cancer

Synonym(s) Familial nonpolyposis colon cancer
Familial nonpolyposis colorectal cancer
Hereditary nonpolyposis colorectal cancer
Lynch syndrome
Prevalence Unknown
Inheritance Autosomal dominant
Age of onset Adult
  • C18
  • C18.0
  • C18.1
  • C18.2
  • C18.3
  • C18.4
  • C18.5
  • C18.6
  • C18.7
  • C18.9
  • C1333990
  • D003123
  • 10051981


Hereditary nonpolyposis colon cancer (HNPCC) is a cancer-predisposing condition characterized by the development of colorectal cancer (CRC), endometrial cancer, and various other cancers (such as malignant epithelial tumor of ovary, gastric, biliary tract, small bowel, and urinay tract cancer) that are frequently diagnosed at an early age. Two types of HNPCC have been reported: Muir-Torre syndrome and non-polyposis Turcot syndrome (see these terms).

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Detailed information

Review article
Clinical practice guidelines
Diagnostic criteria
Guidance for genetic testing
Article for general public
Clinical genetics review
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