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Familial sick sinus syndrome

Disease definition

Sick sinus syndrome is a rare cardiac rhythm disease, usually of the elderly, characterized by electrocardiographic findings of sinus bradycardia, atrial fibrillation, atrial tachycardia sinus arrest, or sino-atrial block, and that manifest with symptoms like syncope, dizziness, palpitations, fatigue, or even heart failure. It results from malfunction of the cardiac conduction system, probably secondary to degenerative fibrosis of nodal tissue in the elderly or secondary to cardiac disorders in younger patients.

ORPHA:166282

  • Synonym(s):
    • Familial sinus node dysfunction
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant or Autosomal recessive 
  • Age of onset: -
  • ICD-10: I49.5
  • OMIM: 163800  182190  608567  614090
  • UMLS: C0037052
  • MeSH: D012804
  • GARD: -
  • MedDRA: 10040639

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