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CLAPO syndrome

Synonym(s) -
Prevalence <1 / 1 000 000
Inheritance Unknown
Age of onset Infancy
  • Q87.3
MeSH -
MedDRA -


Disease definition

CLAPO syndrome is a newly described syndrome consisting of capillary malformation of the lower lip (C), lymphatic malformation of the face and neck (L), asymmetry of face and limbs (A) and partial or generalized overgrowth (O).


It has been described in six unrelated patients.

Clinical description

Capillary malformation of the lower lip is observed in all patients. The overgrowth was noted at birth in three patients but was generalized in only one patient; it was partial in the other patients and involved one or more body segments.

Genetic counseling

Inheritance of this association is not known.

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