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Fetal hydantoin syndrome

Synonym(s) Fetal dihydantoin syndrome
Phenytoin embryofetopathy
Prevalence Unknown
Inheritance Not applicable
Age of onset Neonatal
  • Q86.1
  • C0265372
  • C537922
  • 10016508


Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug phenytoin, characterized by distinct craniofacial anomalies (malformed and low set ears, short neck, short nose and deep nasal bridge, hypertelorism and epicanthal folds) as well as hypoplastic distal phalanges and underdevelopment of nails of fingers and toes, prenatal and postnatal growth retardation, and neurological impairment (at a 2-3 times higher risk than that of the general population) including cognitive deficits and motor developmental delay. Less commonly, microcephaly, ocular defects, oral clefts, umbilical and inguinal hernias, hypospadias and cardiac anomalies have also been reported.

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