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Erythromelalgia

ORPHA1956
Synonym(s) -
Prevalence Unknown
Inheritance Autosomal dominant
Age of onset Childhood
ICD-10
  • I73.8
OMIM -
UMLS
  • C0014804
MeSH
  • D004916
MedDRA
  • 10015284

Summary

Erythromelalgia is a rare neurovascular peripheral pain disorder due to the intermittent blockage of the blood vessels, usually in the lower extremities or hands. This causes hyperemia and inflammation at the origin of burning pain and skin redness. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or stress. Erythromelalgia may occur either as a primary or secondary disorder. Primary erythromelalgia (see this term) is caused by gene mutations. Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, essential thrombocytemia (see this term), hypercholesterolemia, mushroom or mercury poisoning (see this term), and some autoimmune disorders.


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Detailed information

Clinical genetics review
  • EN (2008)
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