Search for a rare disease
Other search option(s)
Semilobar holoprosencephaly is one of the classical forms of holoprosencephaly (HPE; see this term) in which the left and right frontal and parietal lobes are fused and the interhemispheric fissure is only present posteriorly.
About 28% to 54% of HPE patients have semilobar type.
Significant clinical variability and genetic complexity underlie HPE.