This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.Last update: October 2007
It has been described in at least eight patients, in four sibships spanning two generations of a Greek-Cypriot family.
Six other members of the family presented with palmoplantar hyperkeratosis alone.
It is distinct from diffuse idiopathic skeletal hyperostosis (DISH) which is not a rare disease.
This syndrome is likely to be transmitted as an autosomal dominant trait.