Search for a rare disease
Ankylosing vertebral hyperostosis with tylosis
This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.
It has been described in at least eight patients, in four sibships spanning two generations of a Greek-Cypriot family.
Six other members of the family presented with palmoplantar hyperkeratosis alone.
It is distinct from diffuse idiopathic skeletal hyperostosis (DISH) which is not a rare disease.
This syndrome is likely to be transmitted as an autosomal dominant trait.