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Ankylosing vertebral hyperostosis with tylosis

Synonym(s) -
Prevalence <1 / 1 000 000
Inheritance Autosomal dominant
Age of onset Adult
  • M48.1
MeSH -
MedDRA -


Disease definition

This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.


It has been described in at least eight patients, in four sibships spanning two generations of a Greek-Cypriot family.

Clinical description

Six other members of the family presented with palmoplantar hyperkeratosis alone.

Differential diagnosis

It is distinct from diffuse idiopathic skeletal hyperostosis (DISH) which is not a rare disease.

Genetic counseling

This syndrome is likely to be transmitted as an autosomal dominant trait.

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