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Isolated cloverleaf skull syndrome

Synonym(s) -
Prevalence Unknown
Inheritance Not applicable
Age of onset Neonatal
  • Q75.0
MeSH -
MedDRA -


Isolated cloverleaf skull syndrome is a form of craniosynostosis involving multiple sutures (coronal, lambdoidal, sagittal and metopic ) characterized by a trilobular skull of varying severity (frontal towering and bossing, temporal bulging and a flat posterior skull), dysmorphic features (downslanting palpebral fissures, midface hypoplasia, and extreme proptosis) and that is complicated by hydrocephalus, cerebral venous hypertension, developmental delay/intellectual disability and hind brain herniation.

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