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Juvenile primary lateral sclerosis

Disease definition

Juvenile primary lateral sclerosis (JPLS) is a very rare motor neuron disease characterized by progressive upper motor neuron dysfunction leading to loss of the ability to walk with wheelchair dependence, and subsequently, loss of motor speech production.

ORPHA:247604

  • Synonym(s):
    • JPLS
    • Juvenile PLS
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Childhood
  • ICD-10: G12.2
  • OMIM: 606353
  • UMLS: C1853396
  • MeSH: C536416
  • GARD: 4485
  • MedDRA: -

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