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Juvenile amyotrophic lateral sclerosis

Disease definition

Juvenile amyotrophic lateral sclerosis (JALS) is a very rare severe motor neuron disease characterized by progressive upper and lower motor neuron degeneration causing facial spasticity, dysarthria, and gait disorders with onset before 25 years of age.

ORPHA:300605

  • Synonym(s):
    • JALS
    • Juvenile Charcot disease
    • Juvenile Lou Gehrig disease
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Childhood
  • ICD-10: G12.2
  • OMIM: 205100  602099  614373
  • UMLS: -
  • MeSH: -
  • GARD: 11901
  • MedDRA: -

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