Limb girdle muscular dystrophy (LGMD) constitutes a group of genetically determined, progressive muscle weakness disorders, in which the pelvic or shoulder girdle musculature is predominantly or primarily involved. Onset is in adulthood. Different subtypes of LGMD can now be distinguished by means of protein- and genetic analysis. LGMD 1D is transmitted as an autosomal dominant form and has been linked to chromosome 6. No distinguishing features have been noted. Serum creatine kinase (CK) activity is mildly elevated. No specific treatment is known and many patients receive physical therapy to prevent worsening of contractures.
Last update: October 2004