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Primary lateral sclerosis

Synonym(s) Adult-onset PLS
Adult-onset primary lateral sclerosis
Prevalence 1-9 / 100 000
Inheritance Not applicable
or Autosomal recessive
or Autosomal dominant
Age of onset Elderly
  • G12.2
MeSH -
  • 10036704


Disease definition

Primary lateral sclerosis (PLS) is an idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia, and loss of motor speech production.

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