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Acrokeratoelastoidosis of Costa

Synonym(s) AKE
Punctate palmoplantar hyperkeratosis type 3
Punctate palmoplantar keratoderma type 3
Prevalence Unknown
Inheritance Autosomal dominant
or Not applicable
Age of onset Adolescent
  • Q82.8
  • C0545044
  • C535653
MedDRA -


Disease definition

Acrokeratoelastoidosis of Costa is a rare dermatosis characterized by small, firm papules or plaques (resembling warts) on the sides of the hands and feet. These stationary and asymptomatic lesions appear generally at puberty, or sometimes later


The prevalence is unknown.

Differential diagnosis

The histology combines hyperkeratosis and acanthosis.

Genetic counseling

Both autosomal dominant and sporadic forms have been observed.

Management and treatment

Treatment is not indicated in most patients.

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