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Lewis-Sumner syndrome

Synonym(s) MADSAM
Multifocal acquired demyelinating sensory and motor neuropathy
Prevalence 1-9 / 1 000 000
Inheritance Not applicable
Age of onset All ages
  • G61.8
  • C1695985
MeSH -
  • 10065580


Disease definition

Lewis-Sumner syndrome (LSS) is a rare acquired demyelinating polyneuropathy characterized by asymmetrical distal weakness of the upper or lower extremities and motor dysfunction with adult onset. It is considered to be a variant of chronic inflammatory demyelinating polyneuropathy (CIDP; see this term).

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