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Late-onset retinal degeneration

Disease definition

Late-onset retinal degeneration is an inherited retinal dystrophy characterized by delayed dark adaptation and nyctalopia and drusen deposits presenting in adulthood, followed by cone and rod degeneration that presents in the sixth decade of life, which leads to central vision loss. Anterior segment features such as peripupillary iris transillumination defects and abnormally long anterior zonular insertions are also observed. Choroidal neovascularization and glaucoma may occur in the late stages of the disease.

ORPHA:67042

  • Synonym(s):
    • Autosomal dominant late-onset retinal degeneration
    • LORD
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant 
  • Age of onset: Adult, Elderly
  • ICD-10: -
  • OMIM: 605670
  • UMLS: C1854065
  • MeSH: -
  • GARD: 4357
  • MedDRA: -

Additional information

Further information on this disease

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