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Gorham-Stout disease

Orpha number ORPHA73
Synonym(s) Diffuse cystic angiomatosis of bone
Essential osteolysis
Gorham disease
Gorham syndrome
Idiopathic massive osteolysis
Massive osteolysis
Phantom bone disease
Progressive massive osteolysis
Vanishing bone disease
Prevalence Unknown
Inheritance Not applicable
Age of onset All ages
  • M89.5
  • C0029438
MeSH -
  • 10071283


Gorham-Stout disease (GSD) is a congenital vascular bone disease causing massive osteolysis due to proliferation of vascular elements and osteoclasts. GSD may affect any bone in the body and can be monostotic or polyostotic. The most common symptom is localized pain. Other symptoms include swelling, weakness and functional impairment of affected limbs. The disease may be discovered after a pathological fracture.

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