Skip to
  1. Homepage
  2. Rare diseases
  3. Search
Simple search

Simple search

(*) mandatory field


Other search option(s)

Autosomal dominant nail dysplasia

Synonym(s) Onychodystrophy totalis
Twenty-nail dystrophy
Prevalence Unknown
Inheritance Autosomal dominant
Age of onset Childhood
  • L60.3
MeSH -
MedDRA -


Disease definition

Nail dysplasia is an idiopathic nail dystrophy, beginning in early childhood, and characterised by excessive longitudinal striations and loss of nail luster affecting all 20 nails.


Few families have been described.

Differential diagnosis

Histopathological analysis should exclude lichen planus or other skin diseases.

Genetic counseling

Transmission is autosomal dominant.


The disorder progressively resolves.

(*) Required fields.

Attention: Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.