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Addison disease

Disease definition

Addison disease (AD) is a chronic and rare endocrine disorder due to autoimmune destruction of the adrenal cortex and resulting in a glucocorticoid and mineralocorticoid deficiency. Properly speaking AD designates autoimmune adrenalitis, but it is a term commonly used to describe any form of chronic primary adrenal insufficiency (CPAI; see this term).

ORPHA:85138

  • Synonym(s):
    • Autoimmune Addison's disease
    • Autoimmune adrenalitis
    • Classic Addison's disease
    • Primary Addison's disease
  • Prevalence: 1-5 / 10 000
  • Inheritance: -
  • Age of onset: All ages
  • ICD-10: E27.1
  • OMIM: 103230  240200
  • UMLS: C0001403  C0271737
  • MeSH: D000224
  • GARD: 5740
  • MedDRA: 10001130

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