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Mal de Meleda

ORPHA87503
Synonym(s) Keratosis palmoplantaris transgrediens of Siemens
Meleda disease
Transgrediens palmoplantar keratoderma of Siemens
Prevalence 1-9 / 100 000
Inheritance Autosomal recessive
Age of onset Neonatal
Infancy
Childhood
ICD-10
  • Q82.8
OMIM
UMLS -
MeSH -
MedDRA -

Summary

Disease definition

Mal de Melada (MdM) is a diffuse palmoplantar keratoderma initially reported from of the Island of Meleda characterized by symmetric palmoplantar hyperkeratosis that progressively extends to the dorsal surfaces of hands and feet (transgradiens). The disease can be associated to hyperhidrosis, lichenoid plaques and perioral erythema.

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