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Cutaneous leukocytoclastic angiitis

Synonym(s) Cutaneous hypersensitivity vasculitis
Cutaneous leukocytoclastic vasculitis
Cutaneous small vessel vasculitis
Hypersensitivity angiitis
Prevalence Unknown
Inheritance Not applicable
Age of onset All ages
  • M31.0
MeSH -
MedDRA -


Disease definition

Cutaneous leukocytoclastic angiitis is a small-vessel vasculitis presenting with palpable purpura and urticarial lesions which predate the purpuric lesions most frequently observed on the legs. Systemic symptoms including fever, cough, hemoptysis, sinusitis, arthralgia, arthritis, myalgia, abdominal pain, diarrhea, hematochezia, paresthesia, weakness, and hematuria may be observed. Skin biopsy reveals exudates rich in neutrophils, endothelial damage, fibrin deposition, and leukocytoclasis in postcapillary venules of small vessels. Cutaneous leukocytoclastic angiitis can be idiopathic (in up to 50% of cases) or secondary to infections, medications (such as antituberculosis medication), collagen vascular diseases, or neoplasms.

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