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Marcus-Gunn syndrome

Synonym(s) Jaw-winking syndrome
Mandibulo-palpebral synkinesis-ptosis syndrome
Marcus-Gunn phenomenon
Prevalence Unknown
Inheritance Autosomal dominant
Age of onset Infancy
  • Q07.8
MeSH -
  • 10064583


Disease definition

Marcus-Gunn syndrome is characterised by ptosis associated with maxillopalpebral synkinesis.


The syndrome is responsible for 5% of congenital ptoses.

Clinical description

The ptosis is corrected by the opening of the mouth or lateral movements of the lower jaw. This may be due to aberrant innervation of the levator muscle by a branch of the nervus trigeminus.

Differential diagnosis

Inverse Marcus Gunn phenomenon and Marin-Amat syndrome present as eyelid drooping on jaw opening. The first is a congenital condition in which the eyelid levator muscle is inhibited, while Marin-Amat syndrome occurs after facial paralysis and is not associated with impairment of orbicularis oculi and levator muscle function.

Genetic counseling

The syndrome is generally unilateral and sporadic, but bilateral and familial cases with autosomal dominant transmission have been reported.

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