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Marcus-Gunn syndrome

Orpha number ORPHA91412
Synonym(s) Jaw-winking syndrome
Mandibulo-palpebral synkinesis - ptosis
Marcus-Gunn phenomenon
Prevalence Unknown
Inheritance Autosomal dominant
Age of onset Infancy
Neonatal
ICD-10
  • Q07.8
ICD-O -
OMIM
UMLS -
MeSH -
MedDRA
  • 10064583
SNOMED CT
  • 5127009

Summary

Marcus-Gunn syndrome is characterised by ptosis associated with maxillopalpebral synkinesis. The syndrome is responsible for 5% of congenital ptoses. The ptosis is corrected by the opening of the mouth or lateral movements of the lower jaw. This may be due to aberrant innervation of the levator muscle by a branch of the nervus trigeminus. The syndrome is generally unilateral and sporadic, but bilateral and familial cases with autosomal dominant transmission have been reported. Inverse Marcus Gunn phenomenon and Marin-Amat syndrome present as eyelid drooping on jaw opening. The first is a congenital condition in which the eyelid levator muscle is inhibited, while Marin-Amat syndrome occurs after facial paralysis and is not associated with impairment of orbicularis oculi and levator muscle function.


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