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Aase-Smith syndrome

Orpha number ORPHA916
Synonym(s) Aase-Smith I syndrome
Hydrocephalus - cleft palate - joint contractures
Prevalence <1 / 1 000 000
Inheritance
  • Autosomal dominant
Age of onset Neonatal/infancy
ICD-10
  • Q87.8
OMIM
UMLS
  • C0220686
MeSH
  • C535332
MedDRA
  • 10063429
SNOMED CT
  • 71988008

Summary

Aase-Smith syndrome type I is a very rare genetic disorder characterised by the following congenital malformations: hydrocephalus (due to Dandy-Walker anomaly), cleft palate, and severe joint contractures. Less than 20 cases have been reported in the literature. The fingers are thin with absent knuckles and reduced creases over the joints, and patients show an inability to make a full fist. Additional findings may include deformed ears, ptosis, an inability to open the mouth fully, heart defects, and clubfoot. The aetiology remains unknown. There are currently no human genes associated with this disease. Autosomal dominant inheritance is suggested. The features of the hand are especially important for the diagnosis. Clinical overlap between Aase-Smith syndrome I and Gordon syndrome (see this term) has been suggested, due to the presence of distal arthrogryposis and cleft palate in both syndromes. In the absence of a specific treatment, supportive care and surgical correction should be offered.


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