Lobar holoprosencephaly is the mildest classical form of holoprosencephaly (HPE; see this term) characterized by separation of the right and left cerebral hemispheres and lateral ventricules with some continuity across the frontal neocortex, especially rostrally and ventrally.
About 19% of HPE patients have lobar type.
Significant clinical variability and genetic complexity underlie HPE.
- Dr Sandra MERCIER
- Pr Sylvie ODENT