Alobar holoprosencephaly is the most severe classical form of holoprosencephaly (HPE; see this term) characterized by a single brain ventricle and no interhemispheric fissure.
About 15% to 25% of non-chromosomal HPE patients have alobar type.
Significant clinical variability and genetic complexity underlie HPE.
- Dr Sandra MERCIER
- Pr Sylvie ODENT