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Angioma serpiginosum

Orpha number ORPHA95429
Synonym(s) -
Prevalence <1 / 1 000 000
Inheritance Autosomal dominant
X-linked recessive
Not applicable
Age of onset Childhood
ICD-10
  • L81.7
ICD-O -
OMIM
UMLS -
MeSH -
MedDRA -

Summary

Angioma serpiginosum (AS) is a benign congenital skin disease characterised by progressive dilation of the subepidermal skin vessels manifesting as purple punctate lesions usually appearing on the lower limbs and buttocks and following the lines of Blaschko. The disease occurs almost exclusively in females and the majority of cases are sporadic. Only a few familial cases have been reported in the literature so far. Transmission may be autosomal dominant or X-linked. A mutation in the Xp11.3-Xq12 region has been identified in one of the reported families. However, in this family the AS was associated with oesophageal papillomatosis leading to the suggestion that this case of familial AS represents a mild form of focal dermal hypoplasia (see this term).


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